AMP-Dependent Protein Kinase Activators
نویسندگان
چکیده
منابع مشابه
AMP-Dependent Protein Kinase Activators
A patent inability to properly use glycolytic and fatty acid substrates and progressive insulin resistance characterize non–insulin dependent diabetes mellitus. Curiously, the failing myocardium may also share these unfavorable characteristics. Insights from the clinical arena indicate a significant relationship between insulin resistance and New York Heart Association heart failure classificat...
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Myosin light-chain kinase was purifed from bovine carotid artery. Approx. 90% of myosin kinase was extracted in the supernatant fraction with buffer containing EDTA during myofibril preparation. The soluble fraction yielded two distinct peaks on DEAE-Sephacel chromatography. Peak I was eluted at a conductance of 11-12mmho and was completely dependent on Ca2+-calmodulin for its activity. Peak II...
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cAMP-dependent protein kinase (A-kinase) anchoring proteins (AKAPs) are responsible for the subcellular sequestration of the type II A-kinase. Previously, we identified a 78 kDa AKAP which was enriched in gastric parietal cells. We have now purified the 78 kDa AKAP to homogeneity from gastric fundic mucosal supernates using type II A-kinase regulatory subunit (RII) affinity chromatography. The ...
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Objective(s): AMP-activated protein kinase/sirtuin 1 (AMPK/SIRT1) signaling pathway has been proved to be involved in the regulation of autophagy in various models. The aim of this study was to evaluate the effect of AMPK/SIRT1 pathway on autophagy after spinal cord injury (SCI). Materials and Methods:The SCI model was established in rats in vivo and the primary spinal cord neurons were subject...
متن کاملPhosphorylation of casein by cyclic AMP-dependent protein kinase.
Sebastien Taurin, Nathan Sandbo, Yimin Qin, Darren Browning, and Nickolai O. Dulin. From the Department of Medicine, The University of Chicago, Chicago, IL 60637; and the Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA 30912 Running Title: Phosphorylation of β-catenin by PKA *Address correspondence to: Nickolai Dulin, Section of Pulmonary and Critical C...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2009
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.108.192658